In TACTICS-HF, tolvaptan failed to provide a clinically meaningful benefit in patients with acute decompensated heart failure, although patients were enrolled without respect to serum sodium concentrations. Given a consistent trend of disappointing results, does a routine role for the drug exist now or in the future?
Recommended blood pressure goals vary among national practice organizations. One area of controversy is the blood pressure goal for older patients. This piece will review the differences in the recommended blood pressure goals as well as data that may enable clinicians to establish an individualized blood pressure goal for their older patients.